The cause has been suggested as dysfunction of fibroblasts in a localised area of the skin which behave as mucoblasts and secrete excessive mucin. The injuries of follicular mucinosis usually are located in head or more rarely to become general to neck, trunk and extremities. Cutaneous lupus mucinosis also known as papular and nodular mucinosis in lupus erythematosus, papular and nodular mucinosis of gold, and papulonodular mucinosis in lupus erythematosus is a cutaneous condition characterized by lesions that present as asymptomatic skincolored, at times reddish, 0. Majority of the lesions present as asymptomatic nodules which merge with the adjacent mucosa and measures upto 2cm in the greatest. Induction of the disease has been associated with viral processes, solar irradiation. There is a third group of lm that does not have the criteria for either scleromyxedema or the localized form called atypical group. Cutaneous mucinosis is a group of conditions involving an accumulation of mucin or glycosaminoglycan in the skin and its annexes. It has been related to sun exposure, hormonal alterations, rheumatological processes and breast cancer. Clinically it is presented as an asymptomatic elevation, of firm consistency, more frequently localized in the gum or alveolar mucous.
This patient had a history of benign tumors of muscular origin localized in uterus and stomach. Mucinosis is a general term for diseases in which acid. A 28yearold woman presented with an infiltrated erythematous plaque on the left breast. Dermis mucinose eritematosa reticulada information on the. Argyllrobertson reflex argyria argyrophil cell argyrophilic reticular fibre argyrosiderosis. Cutaneous focal mucinosis is a rare entity characterised by asymptomatic flesh coloured papule or nodule occurring commonly on face, trunk or extremities. A case of reticular erythematous mucinosis of histology and atypical localization in a patient with breast cancer, is presented.
Reticular erythematous mucinosis rem is a rare chronic dermatosis that is typically characterized by reticular macular erythema or erythematous papules and plaques on the central area of the chest and back of middleaged women. Since it was not possible to relate these findings to any known syndrome, a combination of the main signs, reticular erythema and mucinosis, was used to name this entity rem syndrome. Reticular erythematous mucinosis, journal of the european. Reticular erythematous mucinosis is a rare syndrome which can be misdiagnosed as seborrhoeic dermatitis.
At present, almost 100 patients with rem syndrome have been described. Dermis mucinose eritematosa reticulada information on. Cutaneous mucinosis in mixed connective tissue disease ncbi. This report concerns two cases of cutaneous mucinosis in patients with mixed connective tissue disease in remission. A diagnosis of reticular erythematous mucinosis rem was made clinically and with the help of histopathology. Mucinosis definition of mucinosis by medical dictionary. We focus on the rareness of this syndrome and its association with other tumors. It is described in some connective tissue diseases but never in association with mixed connective tissue disease. Reticular erythematous mucinosis rem is a skin condition caused by fibroblasts producing abnormally large amounts of mucopolysaccharides. Although the exact etiology remains undefined, efforts to elucidate pathogenesis, disease associations, and prospective treatment modalities have been encouraging. Reticular erythematous mucinosis rem syndrome is a rare, chronic disease characterized by asymptomatic, persistent reticular, slightly infiltrated erythematous plaques on chest andor back with slight infiltration.
Reticular erythematous mucinosis syndrome rem syndrome. Mucinosis is classified by the location of deposition and clinical. These are the first cases of mucinosis described in mixed connective tissue disease. Reticular erythematous mucinosis primary care dermatology. Mucinosis in the oral cavity are not frequent and until this date 38 cases have been reported in literature. Pdf reticular erythematosus mucinosis effectively treated with. Reticular erythematous mucinosis rem, first described relatively recently, is characterized by reticulated erythematous papules coalescing into a plaque on the midupper back or midchest. Jul 12, 2012 reticular erythematous mucinosis rem is a rare cutaneous condition often referred to as plaque. It is described in some connective tissue diseases but never in association with mixed. Stained with he, alcian blue and colloid iron halle. Treatment of reticular erythematous mucinosis with uva1. Reticular erythematous mucinosis rem is a rare form of cutaneous mucinosis, belonging to a heterogeneous group of diseases in which mucin. Mucinoses are a group of cutaneous diseases caused by fibroblasts producing abnormally large amounts of acid mucopolysaccharides i.
Mucinosis eritematosa reticular actas dermosifiliograficas. Reticular erythematous mucinosis rem is a rare cutaneous condition often referred to as plaquelike mucinosis and midline mucinosis. Llinear morphea with secondary mucinosisinear morphea. Jan 06, 2010 reticular erythematous mucinosis syndrome with telangiectasias ayse serap karadag 1, gulcin guler simsek 2 1 department of dermatology, ankara kecioren research and training hospital, ankara, turkey 2 department of pathology, ankara kecioren research and training hospital, ankara, turkey. Reticular erythematous mucinosis open access library.
Franco rongioletti, section of dermatology, chair of dermatopathology, university of genoa,italy. Mucinosis are dermatosis characterised by mucin deposit on the dermis. The healthcare provider may note the characteristic skin rashes a skin biopsy of the affected region, where the tissue is examined by a pathologist under the microscope. Cutaneous mucinosis in mixed connective tissue disease. The abnormal deposits that occur in mucinoses can be localised or widespread. Mucinosis eritematosa reticular reticular erythematous mucinosis. Reticular erythematous mucinosis icd10cm alphabetical index.
It is also called midline mucinosis or plaquelike cutaneous mucinosis. Histological examination of the lesions is necessary to make the diagnosis. Reticular erythematous mucinosis rem is a rare entity characterized by infiltrated erythematous plaques on exposed areas of the thorax and back. Reticular erythematous mucinosis rem, rem syndrome. Mucinoses are a diverse group of uncommon skin disorders. Adult variant of selfhealing cutaneous mucinosis in a. Oral focal mucinosis ofm is a connective tissue lesion which was initially described in 1974 by tomich 1. Pdf zusammenfugen online pdf dateien zusammenfugen. Reticular erythematous mucinosis interstial mucin in the superficial dermis. Clinical features and efficacy of antimalarial treatment. Primary mucinoses dermal lichen myxedematosus reticular erythematous mucinosis rem scleredema pretibial myxedema cutaneous focal mucinosis. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. This is a jellylike complex carbohydrate substance, called hyaluronic acid, that occurs normally as part of the connective tissue in the dermis or midlayer of the skin. Cutaneous focal mucinosis gandhi v, dogra d, pandhi r k.
Aug 01, 2011 skin inflammatory nontumor mucinoses of skin. Reticular erythematous mucinosis rem is a rare cutaneous condition often referred to as plaque. It is a disease that tends to affect women in the third and fourth decades of life. The icd10cm alphabetical index is designed to allow medical coders to look up various medical terms and connect them with the appropriate icd codes. Dermis sindrome rem o mucinosis reticular eritematosa. Papules small bumps develop on the midback or chest and form a netlike pattern hence the name, reticular.
Dieses kostenlose tool erlaubt es mehrere pdfs oder bilddateien miteinander zu einem pdfdokument zu verbinden. Background reticular erythematous mucinosis rem syndrome is a rare cutaneous disease that predominantly affects the chest and upper back area of middleaged women. Reticular erythematous mucinosis rem is rare form of cutaneous mucinosis. Although the exact etiology remains undefined, efforts to elucidate pathogenesis, disease associations, and prospective. Reticular erythematous mucinosis what exactly is this. Llinear morphea with secondary mucinosisinear morphea with. The healthcare provider may note the characteristic skin rashes a skin biopsy of the affected region, where the tissue.
The leading primary care society for dermatology and skin surgery. Reticular erythematous mucinosis rem is characterized by persistent, mildly pruritic, reticulated erythematous macules, papules or urticarial plaques that most often occur on the upper back and chest figure 1. Treatment is rarely necessary due to the absence of. Sep 03, 20 reticular erythematous mucinosis rem, first described relatively recently, is characterized by reticulated erythematous papules coalescing into a plaque on the midupper back or midchest. Allergies can make mucinosis worse and i frequently see flareups in dogs with allergic dermatitis coinciding with their itchy skin disease. A 48 year old male developed erythema on the face and neck with infiltrated papuloplaque lesions on the neck region.
Cutaneous mucinosis covers a heterogeneous group of diseases involving a diffuse and or focal mucin accumulation in the skin and its annexes. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Papulonodular mucinosis in systemic lupus erythematosus. Reticular erythematous mucinosis definition of reticular. All involve accumulation in the skin of abnormal amounts of mucin. A diagnosis of reticular erythematous mucinosis may involve. Papulonodular mucinosis in systemic lupus erythematosus victoria g ortiz md a, ravi s krishnan md a, ling l chen md b, and sylvia hsu md a dermatology online journal 10 2. Reticular erythematous mucinosis, he 10x 604 reticular erythematous mucinosis, alcian blue 10x 605 reticular erythematous mucinosis, halle 10x 606 reticular erythematous mucinosis, he 40x 607 reticular erythematous mucinosis, alcian blue 40x 608 reticular erythematous mucinosis, halle 40x 609. Investigations including hematological, biochemical, serum and urine protein electrophoresis, thyroid function tests and antinuclear antibody ana were normal. Researched pathways related to reticular erythematous mucinosis include pathogenesis, cell adhesion, immune response, response to interleukin1, photoprotection. There are 0 terms under the parent term reticular erythematous mucinosis in the icd10cm alphabetical index.
A physical examination and evaluation of complete medical history. These are most commonly seen on the chest and upper back. Although the exact etiology remains undefined, efforts to. Jan 11, 2019 reticular erythematous mucinosis rem is a rare, benign skin condition that causes welldefined red rashes on the skin. Although antimalarial treatment is generally considered the most effective approach, only a few case reports exist on its use in rem syndrome. A diagnosis of morphea with secondary mucinosis was made and oral minipulse steroid therapy with. The study of reticular erythematous mucinosis has been mentioned in research publications which can be found using our bioinformatics tool below. Jun 17, 2012 cutaneous mucinosis is a group of conditions involving an accumulation of mucin or glycosaminoglycan in the skin and its annexes. Feb 14, 2017 alopecia mucinosa, often referred to as follicular mucinosis, was first reported by pinkus in 1957. The presence of single or multiple welldelineated erythematous plaques with alopecia is the typical presentation. Cutaneous mucinosis is a group of conditions involving an accumulation of mucin. This is a picture of sharpei skin with cutaneous mucinosis.
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